Clean and trim the chicken livers, removing any connective tissue. Pat them as dry as you can get them.
In a bowl, beat the eggs with hot sauce, smoked paprika, garlic powder, onion powder, cayenne pepper (optional), salt, and pepper to taste until smooth. This adds flavor and gives the coating something to cling to. The hot sauce is optional.
In a shallow dish, plastic bag, or paper bag, combine the flour, breadcrumbs, smoked paprika, garlic powder, onion powder, and optional cayenne pepper.
Take each liver, dip it into the egg mixture, let the excess drip off, then coat it fully in the flour-breadcrumb mix. Press the coating on firmly so it sticks. I like to use a bag, and then shake it up to ensure the breading adheres.
Place the breaded livers on a plate or rack and let them sit for 10 minutes. This helps the crust stay intact when frying.
Heat the oil to 350–365°F. Use a deep skillet or Dutch oven with enough oil to line 1-2 inches of the bottom of the pan.
Fry in batches. Carefully drop the livers into the hot oil and fry for about 3–4 minutes per side, until golden brown and crispy on the outside. The breading should be golden brown and crispy, and the inside should still be slightly pink but not raw. A quick thermometer check, 165°F is foolproof.
Drain the livers. Remove and place on a wire rack to let any excess oil drip away.
Serve hot. Enjoy immediately with more hot sauce, ranch, or classic Southern sides.